Canadian Biotech's New Alzheimer Treatment

April 26, 2019

For patients and their families who live with dementia -- and those committed to its treatment and prevention - the cost of the disease is extraordinarily high and the need for new solutions is urgent.

The need to take action, improve treatment, and pursue the eventual prevention of Alzheimer's disease, is great. Unfortunately, the field has seen only failure while searching for therapeutic interventions that alter the inextricable course of the disease. In recent years, Canadian biotech companies have assembled groups of esteemed Canadian researchers and international collaborators to create multi-faceted teams that are pushing the boundaries of what's possible in brain health research.

KalGene Pharmaceuticals is one such company, focused on developing a unique Alzheimer's disease therapeutic agent. Using methodologies spanning basic molecular science to pre-clinical models, using biomarkers and translational imaging, the company is now engaged in advanced biomanufacturing and early patient identification to enter clinical development. The company is well-positioned to use key national resources for clinical proof of principle, and leverage big biotech and pharma commercial infrastructure to provide hope for patients.

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KalGene Pharmaceuticals Appoints James E. Callaway, Ph.D. as Chief Executive Officer

January 4, 2019

KalGene Pharmaceuticals Inc., a biotechnology company developing therapeutics to slow the progression of Alzheimer's disease, today announced the appointment of James Callaway, Ph.D. as chief executive officer, effective immediately.

"This has been a very important transition year as we have confirmed our initial thesis with respect to validating the company's lead KG207, which in pre-clinical studies was shown to successfully cross the blood brain barrier and safely reduce plaque load.  The company has successfully completed early toxicology studies and has carried out all the requisite steps to manufacture product," said Dr. Jacki Jenuth, Chairperson of the Kalgene's board of directors.  "We are very pleased to have executed on the next key step of our strategy in attracting an accomplished new CEO to the company as we leverage this foundation and address significant inbound interest for the company and its lead program.  Jim brings an ideal set of leadership skills and domain expertise to guide the team through the transition from a pre-clinical to a clinical stage company."

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KalGene Pharmaceuticals Inc., NRC, CIMTEC and McGill to Present Ground-Breaking Preclinical Data During Alzheimer’s Disease Program at AAIC 2017

July 14, 2017

KalGene Pharmaceuticals Inc., in collaboration with the National Research Council of Canada (NRC), CIMTEC and the McGill Centre for Studies in Aging, have demonstrated that KalGene’s Alzheimer’s therapeutics candidate, licensed from the NRC (KAL-ABP-BBB), crosses the blood-brain barrier, and reduces amyloid-beta burden in a transgenic rat model after a four (4) week treatment. The results will be presented by McGill’s Dr. Pedro Rosa-Neto and the NRC’s Dr. Balu Chakravarthy at the Alzheimer’s Association International Conference (AAIC) in London in July 2017.  

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KalGene gears up to manufacture and test promising Alzheimer’s treatment with NRC, McGill and CIMTEC

October 3, 2016

KalGene Pharmaceuticals and the National Research Council of Canada (NRC) are proud to announce the signature of an agreement worth over $1M to develop, scale up, and transfer the technology needed to manufacture a promising novel Alzheimer’s treatment in Canada that the parties have been co- developing since 2015.

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NRC and KalGene Develop New Alzheimer's Treatment

June 5, 2015

Canadian biotech KalGene Pharmaceuticals has successfully secured $1.5 million in financing from Brain Canada, CQDM, and the Ontario Brain Institute (OBI) Focus on Brain program to develop a new treatment for Alzheimer's. This funding from CQDM will allow KalGene to test the conjugated therapeutic in preclinical models and if successful, in patients. 

National Research Council of Canada and KalGene Pharmaceuticals announce license agreement for the development of novel Alzheimer’s therapeutics

January 13, 2015

 National Research Council of Canada (NRC) has granted KalGene Pharmaceuticals an exclusive worldwide license for a therapeutic molecule against Alzheimer’s disease.

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